It's been suggested on politcs.SE (but the question was closed as off-topic there) that a US vice-president needs to comply with 5 CFR §2635.502 which sets stricter standards for conflicts of interest than 18 USC § 209. In the regulations the mere appearance of conflict of interest is ground for recusal ("the employee should not participate in the matter"), but allows an "agency designee" to waive this.
My impression is that 2635.502 doesn't apply to a US vice-president because he is not an employee but an officer whereas 18 USC § 209 clearly applies to both officers and employees (both categories are mentioned in the latter, only employees in the former). As for why there would be such a discrepancy, i.e. a lower conflict-of-interest standard for the officers, there's parallel with the recusal of supreme justices, who aren't held to the higher recusal standard of 28 USC 455 presumably because the supreme justices are aren't as easily replaceable [on a case] as lower-level federal judges.
Is this reasoning correct, basically, i.e. does 5 CFR §2635.502 not apply to a US vice-president?