Article 2 section 3 of the United States Constitution states, in part:
"[The President] shall take Care that the Laws be faithfully executed" (Source: https://constitution.congress.gov/browse/essay/artII-S3-1-3-1/ALDE_00001160/['impeachment'])
At issue here is not whether the President can de-prioritize enforcement of a law, but whether the President can outright refuse to enforce it simply because they don't agree with it.
For example, were President Biden or anyone with authority over Immigration and Customs Enforcement to issue a memorandum that says "United States Immigration and Customs Enforcement is hereby permanently prohibited from making any more arrests for violations of immigration law" would that memorandum be enforceable under the Constitution, or would ICE be legally allowed, or even required, to disregard the memorandum?