how can one find a comprehensive enumeration of all the precedent setting cases that pertain to a particular issue or the application of a particular statute?
The Law Society provides this research service where specially trained people scour through all relevant databases and return to you what they have found. Though this service is only available to lawyers (and other people associated with the profession), a lawyer can submit a request for you. Find one that charges in 15-min (or less) time chunks (instead of rounding up to hours) and the price will be reasonable.
Comprehensive databases are available commercially e.g. CaseBase, though subscriptions typically cost several thousand $ per annum.