No, given McGowan v. Maryland, 366 U.S. 420, Braunfeld v. Brown, 366 U.S. 599 and In Two Guys from Harrison-Allentown, Inc. v. McGinley, 366 U.S. 582.
The principle is that laws with religious origins are constitutional if they have a secular purpose. In Braunfeld, the defendants who were Orthodox Jews could not operate their business from sunfall to sunfall on Friday-Saturday, and sought to operate on Sunday contrary to a Pennsylvanis law prohibiting retail sales of their commodities on Sunday. The court rules that the law "does not violate the Equal Protection Clause of the Fourteenth Amendment, nor constitute a law respecting an establishment of religion, and it does not prohibit the free exercise of appellants' religion, within the meaning of the First Amendment, made applicable to the States by the Fourteenth Amendment". Their argument was based on the fact that to comply with the requirements of their religion plus the statutes of Pennsylvania, they would suffer economic loss. The court historically reviewed blue laws and concluded that the requirement to be closed on Sunday is not necessarily tied to religion, noting for example that in 1776 Virginia seemed that "all men are equally entitled to the free exercise of religion" and repealed laws penalizing expression and observations of religions, but also maintained laws prohibiting Sunday labor. Restrictions are possible on "people's actions when they are found to be in violation of important social duties or subversive of good order, even when the actions are demanded by one's religion".
The matter has not come before SCOTUS since then (the constitutionality of blue laws is now "established law", until these rulings are overturned, analogous to Dobbs overturning Roe).